HFE c282y homozygotes are at increased risk of breast and colorectal cancer

NJ Osborne; LC Gurrin; KJ Allen; CC Constantine; MB Delatycki; CE McLaren; DM Gertig; GJ Anderson; MC Southey; JK Olynyk; LW Powell; JL Hopper; GG Giles; DR English

Journal article

HFE c282y homozygotes are at increased risk of breast and colorectal cancer

NJ Osborne, LC Gurrin, KJ Allen, CC Constantine, MB Delatycki, CE McLaren, DM Gertig, GJ Anderson, MC Southey, JK Olynyk, LW Powell, JL Hopper, GG Giles, DR English

Hepatology | WILEY | Published : 2010

DOI: 10.1002/hep.23448

Abstract

The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 28,509) were genotyped for the HFE C282Y (substitution of tyrosine for cysteine at amino acid 282) variant. Incident cancers were ascertained from Australian cancer registries during an average of 14 years follow-up. Hazard ratios (HRs), confidence intervals (CIs), and P values were obtained from separate Cox regression analyses for colorectal, breast, and prostate cancers, all other so..

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University of Melbourne Researchers

Lyle Gurrin Author

Martin Delatycki Author

Dorota Gertig Author

Melissa Southey Author

Related Projects (3)

GENETIC MODIFIERS OF HEMOCHROMATOSIS

DESCRIPTION (provided by applicant): Hereditary hemochromatosis (HH) is a common disorder of iron overload and over 80% of patients are homo..

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One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortali..

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Grants

Awarded by National Institute of Diabetes and Digestive and Kidney Diseases

Funding Acknowledgements

The research was funded by grants from the National Health and Medical Research Council, Australia (251668, 209057), and the U.S. National Institutes of Health (5-R01-DK-061885-03). J.K.O. and M.B.D. are the recipients of Practitioner Fellowships, G.A. is Senior Research Fellow. J.L.H. is the recipient of an Australia Fellowship, and L.C.G. and K.J.A. are the recipients of Career Development Awards, all from the Australian National Health and Medical Research Council.